Impaired Na+,K+ATPase activity in red blood cells in euthyroid women treated with levothyroxine after total thyroidectomy for Graves' disease

In patients suffering from hyperthyroidism dependent on Graves' disease, a reduction in Na+,K+ATPase activity has been demonstrated in red blood cells (RBCs), as well as an inverse correlation between this enzymatic action and free triiodothyronine (FT3) levels. The restoration of normal FT3 values also brings about a normalization of Na+,K+ATPase activity in erythrocytes.

NB. after total thyroidectonomy in 2 groups Graves and nontoxic and diffuse nodular goiter(NDNG)

the activity of Na+,K+ATPase in RBCs was once again reduced (NOT normalised despite T4 only replacement in GG,
while normal in GC (who also received T4 only replacement) who underwent total thyroidectomy for nontoxic and diffuse nodular goiter (group control [GC])

So it was something to do with the Graves antibodies?

Note normalization of Na+,K+ATPase activity in erythrocytes was achived during antithyroid therapy with the Graves subjects.
This suppressed the antibody level?

Thionamide treatment restored the normal activity of the Na/K pump, accompanied by normalization of the number of ouabain-binding sites

Me thoughts so far all below..I'm trying to make sense of observation on what happens with myself and friends

In low (inadequate) cortisol state,
K+ UP (maybe high in normal range)

Na+ DOWN (maybe low in normal range)

as Na+,K+ATPase DOWN has reduced activity..impaired..(working slow)

FT3 UP (near top or above normal range)
this is as the FT3 is not being used up (broken down if you insist!)
------------

A friend , G, was given a K+ drip for a low K+ state, and found her FT3 was above range immediately after.
Assumed test results on 100 mcg thyroxin
before drip..
FT4 18, unknown but not known to be highish in range on T4 alone b4 , TSH 2+
After drip
FT4 11, FT3 near top of range, TSH 2+

It appears the K+ drip caused K+ to go high??
My thoughts, this happened due to a a reduction in Na+,K+ATPase activity.. therefore FT3 increased(same as in the low cortisol case I think)as the FT3 couldn't be used (broken down) due to the lowering activity of the Na+,K+ATPase pump.

Hey G, is this what happened?

also found
Plasma renin and aldosterone in thyroid diseases
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?